This is big news, since it will be the first time a prediction has been made in the Los Angeles area. See: Risk of big earthquake on San Andreas fault rises after quake swarm at Salton Sea. [Thanks to Pierre Picard for the citation.]

Although the prospect of an earthquake is scary, CA is probably the best prepared state in the nation to deal with earthquakes.  See this CA Earthquake Timeline chart the Diva and others prepared in 2008, which shows the significant mitigation efforts taken.
By the way, if anyone would like to support an updated version of that chart, please let me know.